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OCR: enance usually For chronic adrenocortical failure, mair therapy with hydrocortisone is initiated .ce the together with 90-fludrocortisone to rep mineralocorticoid deficiency. Mineralocorticoid replacement with ron 9%-fludrocortisone is given either daily ng on alternate days; the dose varies from 0.05 alternate days, to 0.2mg daily. If the dose result. excessive, oedema and hypertension m ent can be Adequacy of mineralocorticoid replacer nin monitored by measurement of plasma sually activity. Elevated plasma renin activity signifies that inadequate mineralocortic wice-daily replacement has been given. In practice ippression 90-fludrocortisone may provide better s of renin than once-daily therapy. See also: · Adrenal Cortex Physiology.